Please use this identifier to cite or link to this item: https://repository.usc.edu.co/handle/20.500.12421/521
Title: In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine
Authors: Yepes, Edward
Varela-M, Rubén E.
López-Abán, Julio
Habib Dakir, E. L.
Mollinedo, Faustino
Muro, Antonio
Issue Date: 2014
Publisher: PLoS ONE
Abstract: Schistosomiasis is a parasitic disease caused by trematodes of the genus Schistosoma. Five species of Schistosoma are known to infect humans, out of which S. haematobium is the most prevalent, causing the chronic parasitic disease schistosomiasis that still represents a major problem of public health in many regions of the world and especially in tropical areas, leading to serious manifestations and mortality in developing countries. Since the 1970s, praziquantel (PZQ) is the drug of choice for the treatment of schistosomiasis, but concerns about relying on a single drug to treat millions of people, and the potential appearance of drug resistance, make identification of alternative schistosomiasis chemotherapies a high priority. Alkylphospholipid analogs (APLs), together with their prototypic molecule edelfosine (EDLF), are a family of synthetic antineoplastic compounds that show additional pharmacological actions, including antiparasitic activities against several protozoan parasites.
URI: https://repository.usc.edu.co:8443/xmlui/handle/123456789/521
ISSN: 1932-6203
Appears in Collections:Producción Científica

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