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Title: Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
Authors: Vera Lizcano, Omaira
Resende, Sarah Stela
Chehuan, Yonne F.
Guimarães Lacerda, Marcus Vinicius
A. Brito, Cristiana F.
Zalis, Mariano G.
Keywords: Plasmodium vivax;chloroquine;resistance
Issue Date: 2014
Publisher: Memorias do Instituto Oswaldo Cruz
Abstract: The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
ISSN: 0074-0276
Appears in Collections:Producción Científica

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