Please use this identifier to cite or link to this item: https://repository.usc.edu.co/handle/20.500.12421/519
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dc.contributor.authorYepes, Edward-
dc.contributor.authorVarela-M, Rubén E.-
dc.contributor.authorLópez-Abán, Julio-
dc.contributor.authorRojas-Caraballo, Jose-
dc.contributor.authorMuro, Antonio-
dc.contributor.authorMollinedo, Faustino-
dc.date.accessioned2019-08-08T05:58:29Z-
dc.date.available2019-08-08T05:58:29Z-
dc.date.issued2015-
dc.identifier.issn1935-2727-
dc.identifier.urihttps://repository.usc.edu.co:8443/xmlui/handle/123456789/519-
dc.description.abstractSchistosomiasis is the third most devastating tropical disease worldwide caused by blood flukes of the genus Schistosoma. This parasitic disease is due to immunologic reactions to Schistosoma eggs trapped in tissues. Egg-released antigens stimulate tissue-destructive inflammatory and granulomatous reactions, involving different immune cell populations, including T cells and granulocytes. Granulomas lead to collagen fibers deposition and fibrosis, resulting in organ damage. Praziquantel (PZQ) is the drug of choice for treating all species of schistosomes. However, PZQ kills only adult Schistosoma worms, not immature stages. The inability of PZQ to abort early infection or prevent re-infection, and the lack of prophylactic effect prompt the need for novel drugs and strategies for the prevention of schistosomiasis.en_US
dc.language.isoenen_US
dc.publisherPLoS Neglected Tropical Diseasesen_US
dc.titleInhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel.en_US
dc.typeArticleen_US
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