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Title: Purification Methodology for Viable and Infective Plasmodium vivax Gametocytes That Is Compatible with Transmission-Blocking Assays.
Authors: Vera, Omaira
de Brito, Paula Brelas
Albrecht, Letusa
Martins-Campos, Keillen Monick
P. Pimenta, Paulo F.
Monteiro, Wuelton M.
G. Lacerda, Marcus V.
P. Lopes, Stefanie C.
M. Costa, Fabio T.
Issue Date: 2015
Publisher: Antimicrobial Agents and Chemotherapy
Abstract: Significant progress toward the control of malaria has been achieved, especially regarding Plasmodium falciparum infections. However, the unique biology of Plasmodium vivax hampers current control strategies. The early appearance of P. vivax gametocytes in the peripheral blood and the impossibility of culturing this parasite are major drawbacks. Using blood samples from 40 P. vivax-infected patients, we describe here a methodology to purify viable gametocytes and further infect anophelines. This method opens new avenues to validate transmission-blocking strategies.
ISSN: 1098-6596
Appears in Collections:Producción Científica

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