Please use this identifier to cite or link to this item:
Title: When Serendipity Knocks on the Door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one
Authors: Carmona-Vargas, Christian C.
Ellena, Javier
D’Vries, Richard F.
Chaur, Manuel N.
Keywords: chlorination;thiobarbituric acid;serendipity;thiazolopyrimidine
Issue Date: 2019
Publisher: Journal of the Brazilian Chemical Society
Abstract: Herein, we present the serendipitous obtaining of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one in 40% yield by using POCl3 and a thiobarbituric acid derivative. The thiazolopyrimidine derivative was characterized by 1H nuclear magnetic resonance (NMR), UV-Vis, and Fourier transform infrared (FTIR) spectroscopy. Additionally, the structure was confirmed by single crystal X-ray diffraction, where it was found that the compound crystallizes in the P-1 triclinic space group with two conformeric molecules of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one by asymmetric unit. Also, from the structural data was studied the supramolecular interactions using Hirshfeld surface analysis and 2D fingerprint plots.
ISSN: 1678-4790
Appears in Collections:Producción Científica

Files in This Item:
File Description SizeFormat 
When_Serendipity_Knocks_on_the_Door_Synthesis_and_.pdf2,1 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.