Please use this identifier to cite or link to this item: https://repository.usc.edu.co/handle/20.500.12421/357
Title: Human papillomavirus in upper digestive tract tumors from three countries
Authors: Castillo, Andrés
Koriyama, Chihaya
Higashi, Michiyo
Anwar, Muhammad Maqsood
Bukhari, Mulazim Hussain
Carrascal, Edwin
Mancilla, Lida I.
Matsumoto, Matsutaka
Sugihara, Kazumasa
Natsugoe, Shoji
Eizuru, Yoshito
Akiba, Suminori
Okumura, Hiroshi
Keywords: E6
Human papillomavirus
p16INK4a
P53
Physical status
Viral load
Protein p16
Protein p53
Digestive system cancer
Esophagus carcinoma
Human tissue
Nonhuman
Carcinoma, Squamous Cell
Aged
Cell Transformation, Neoplastic
Middle Aged
Colombia
Japan
Pakistan
Oncogene Proteins, Viral
Issue Date: 28-Dec-2011
Abstract: AIM: To clarify human papillomavirus (HPV) involvement in carcinogenesis of the upper digestive tract of virological and pathological analyses. METHODS: The present study examined the presence of HPV in squamous cell carcinomas of the oral cavity (n = 71), and esophagus (n = 166) collected from Japan, Pakistan and Colombia, with different HPV exposure risk and genetic backgrounds. The viral load and physical status of HPV16 and HPV16-E6 variants were examined. Comparison of p53 and p16INK4a expression in HPV-positive and HPV-negative cases was also made. RESULTS: HPV16 was found in 39 (55%) oral carcinomas (OCs) and 24 (14%) esophageal carcinomas (ECs). This site-specific difference in HPV detection between OCs and ECs was statistically significant (P < 0.001). There was a significant difference in the geographical distribution of HPV16-E6 variants. Multiple infections of different HPV types were found in 13 ECs, but multiple infections were not found in OCs. This difference was statistically significant (P = 0.001). The geometric means (95% confidence interval) of HPV16 viral load in OCs and ECs were 0.06 (0.02-0.18) and 0.12 (0.05-0.27) copies per cell, respectively. The expression of p16INK4a proteins was increased by the presence of HPV in ECs (53% and 33% in HPV-positive and -negative ECs, respectively; P = 0.036), and the high-risk type of the HPV genome was not detected in surrounding normal esophageal mucosa of HPV-positive ECs. CONCLUSION: Based on our results, we cannot deny the possibility of HPV16 involvement in the carcinogenesis of the esophagus. © 2011 Baishideng. All rights reserved.
URI: https://repository.usc.edu.co/handle/20.500.12421/357
ISSN: 10079327
Appears in Collections:Artículos Científicos

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