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dc.contributor.authorGarrido‐Suárez, Bárbara B.
dc.contributor.authorGabino Garrido, Gabino
dc.contributor.authorPiñeros, Octavio
dc.contributor.authorDelgado Hernández, René
dc.date.accessioned2020-02-10T01:03:21Z
dc.date.available2020-02-10T01:03:21Z
dc.date.issued2019-11-22
dc.identifier.issn0951418X
dc.identifier.urihttps://repository.usc.edu.co/handle/20.500.12421/2693
dc.description.abstractOsteoarthritis (OA) pain has been proposed to be a mixed pain state, because in some patients, central nervous system factors are superimposed upon the more traditional peripheral factors. In addition, a considerable amount of preclinical and clinical evidence has shown that, accompanying the central neuroplasticity changes and partially driven by a peripheral nociceptive input, a real neuropathic component occurs that are particularly linked to disease severity and progression. Hence, innovative strategies targeting neuroprotection and particularly neuroinflammation to prevent and treat OA pain could be introduced. Mangiferin (MG) is a glucosylxanthone that is broadly distributed in higher plants, such as Mangifera indica L. Previous studies have documented its analgesic, anti‐inflammatory, antioxidant, neuroprotective, and immunomodulatory properties. In this paper, we propose its potential utility as a multitargeted compound for mixed OA pain, even in the context of multimodal pharmacotherapy. This hypothesis is supported by three main aspects: the cumulus of preclinical evidence around this xanthone, some preliminary clinical results using formulations containing MG in clinical musculoskeletal or neuropathic pain, and by speculations regarding its possible mechanism of action according to recent advances in OA pain knowledge.es
dc.language.isoenes
dc.publisherJohn Wiley and Sons Ltdes
dc.subjectHyperalgesiaes
dc.subjectMangiferines
dc.subjectNeuroprotectiones
dc.subjectOA paines
dc.titleMangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic paines
dc.typeArticlees


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