Please use this identifier to cite or link to this item:
Title: Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain
Authors: Garrido‐Suárez, Bárbara B.
Gabino Garrido, Gabino
Piñeros, Octavio
Delgado Hernández, René
Keywords: Hyperalgesia;Mangiferin;Neuroprotection;OA pain
Issue Date: 22-Nov-2019
Publisher: John Wiley and Sons Ltd
Abstract: Osteoarthritis (OA) pain has been proposed to be a mixed pain state, because in some patients, central nervous system factors are superimposed upon the more traditional peripheral factors. In addition, a considerable amount of preclinical and clinical evidence has shown that, accompanying the central neuroplasticity changes and partially driven by a peripheral nociceptive input, a real neuropathic component occurs that are particularly linked to disease severity and progression. Hence, innovative strategies targeting neuroprotection and particularly neuroinflammation to prevent and treat OA pain could be introduced. Mangiferin (MG) is a glucosylxanthone that is broadly distributed in higher plants, such as Mangifera indica L. Previous studies have documented its analgesic, anti‐inflammatory, antioxidant, neuroprotective, and immunomodulatory properties. In this paper, we propose its potential utility as a multitargeted compound for mixed OA pain, even in the context of multimodal pharmacotherapy. This hypothesis is supported by three main aspects: the cumulus of preclinical evidence around this xanthone, some preliminary clinical results using formulations containing MG in clinical musculoskeletal or neuropathic pain, and by speculations regarding its possible mechanism of action according to recent advances in OA pain knowledge.
ISSN: 0951418X
Appears in Collections:Artículos Científicos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.