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Antitumor activity of artemisinin and its derivatives: From a well-known antimalarial agent to a potential anticancer drug

Crespo-Ortiz, Maria del Pilar; Wei, Ming (2012-08-23)

Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells. Artemisinin and its analogs are naturally occurring ...

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

Xie, Stanley C.; Dogovski, Con; Hanssen, Eric; Chiu, Francis; Yang, Tuo; Crespo, Maria P.; Stafford, Che A.; Batinovic, Steven; Teguh, Silvia C.; Charman, Susan A.; Klonis, Nectarios; Tilley, Leann M. (Company of Biologists Ltd, 2016-01-01)

Current first-line artemisinin antimalarials are threatened by the emergence of resistant Plasmodium falciparum. Decreased sensitivity is evident in the initial (early ring) stage of intraerythrocytic development, meaning ...