Now showing items 1-5 of 5
Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis
(BioMed Central Ltd., 2017-10-10)
Background: Leishmaniasis is one of the world's most neglected diseases caused by at least 20 different species of the protozoan parasite Leishmania. Although new drugs have become recently available, current therapy for ...
Antitumor activity of artemisinin and its derivatives: From a well-known antimalarial agent to a potential anticancer drug
Improvement of quality of life and survival of cancer patients will be greatly enhanced by the development of highly effective drugs to selectively kill malignant cells. Artemisinin and its analogs are naturally occurring ...
Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies
(Universidad Santiago de Cali, 2015-09-01)
An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes ...
(Sociedad Chilena de Infectologia, 2016-08-06)
Strongyloidiasis is an infection caused by the parasite Strongyloides stercoralis, which can be asymptomatic and means a high morbidity and mortality in immunocompromised hosts, severe malnutrition and coinfection with ...
The Akt-like kinase of Leishmania panamensis: As a new molecular target for drug discovery
(Elsevier B.V., 2018-01-01)
The Akt-like kinase of Leishmania spp. is a cytoplasmic orthologous protein of the serine/threonine kinase B-PKB/human-Akt group, which is involved in the cellular survival of these parasites. By the application of a ...