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Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

Xie, Stanley C.; Dogovski, Con; Hanssen, Eric; Chiu, Francis; Yang, Tuo; Crespo, Maria P.; Stafford, Che A.; Batinovic, Steven; Teguh, Silvia C.; Charman, Susan A.; Klonis, Nectarios; Tilley, Leann M. (Company of Biologists Ltd, 2016-01-01)

Current first-line artemisinin antimalarials are threatened by the emergence of resistant Plasmodium falciparum. Decreased sensitivity is evident in the initial (early ring) stage of intraerythrocytic development, meaning ...