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When serendipity knocks on the door: Synthesis and Physicochemical Characterization of 7-Chloro-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-one
(Sociedade Brasileira de Quimica, 2019-03-19)
Herein, we present the serendipitous obtaining of 7-chloro-2,3-dihydro-5H-thiazolo [3,2-a]pyrimidin-5-one in 40% yield by using POCl3 and a thiobarbituric acid derivative. The thiazolopyrimidine derivative was characterized ...
Mechanochemical Synthesis of a Multicomponent Solid Form: The Case of 5-Fluorocytosine Isoniazid Codrug
(American Chemical Society, 2018-07-12)
Mechanochemistry synthesis was applied to the supramolecular synthesis and green scale-up production of a 1:1 drug–drug cocrystal involving the antimetabolite prodrug 5-Fluorocytosine (5-FC) and the tuberculostatic drug ...
Avoiding irreversible 5-fluorocytosine hydration: Via supramolecular synthesis of pharmaceutical cocrystals
(Royal Society of Chemistry, 2018-07-27)
The antimetabolite 5-fluorocytosine (5-FC) was used to form pharmaceutical cocrystals in order to modulate its poor physicochemical stability in humid environments, which leads to the irreversible incorporation of a water ...
Spergulagenic Acid A: Isolation and single crystal structure elucidation
(Elsevier B.V., 2019-07-19)
In the present work, the crystal structure of (3b)-3-acetoxy-30-methoxy-30-oxo-olean-12-en-28-oic acid, (Spergulagenic Acid A) is presented. The compound was isolated from Cecropia telenitida roots, employing semi-pilot ...
1D lanthanide coordination polymers based on lanthanides and 4′-hydroxi-4-biphenylcarboxylic acid: Synthesis, structures and luminescence properties
(Academic Press Inc., 2019-03-29)
Synopsis: A family of coordination polymers with formula [Ln(4-OHBBA) 3 (H 2 O) 2 ] with a new 3D supramolecular network topology was obtained. Luminescence properties were studied. Resume: A new family of 1D coordination ...
Novel Isoniazid cocrystals with aromatic carboxylic acids: Crystal engineering, spectroscopy and thermochemical investigations
(Elsevier B.V., 2017-09-30)
Four novel cocrystals of the anti-tuberculosis drug Isoniazid (INH), including two polymorphs, with the aromatic carboxylic acids p-nitrobenzoic (PNBA), p-cyanobenzoic (PCNBA) and p-aminobenzoic (PABA) were rationally ...
Data of synthesis, characterization and luminescence measurements in 1D lanthanide coordination polymers based on lanthanides
(Elsevier Inc., 2019-10-22)
In this work are presented all the conditions of synthesis explored to obtain a new family of compound with formula [Ln(4-OHBBA)3(H2O)2] (Ln = La, Pr). Powder X ray diffraction was used to identify the different phases ...
Order-disorder phase transition induced by proton transfer in a co-crystal of 2,4-dichlorobenzoic acid and trimethylamine: N -oxide
(Royal Society of Chemistry, 2017-06-05)
A crystalline binary adduct between trimethylamine N-oxide (TMANO) and 2,4-dichlorobenzoic acid (2,4-DCBA) molecules was obtained by slow evaporation from acetonitrile. The obtained molecular complex is formed by a racemic ...